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Patents
- Macrocyclic Peptidomimetics with Nanomolar Antifungal and Antimicrobial Activity. US Patent WO 2014/182839 A1, 2014.
- Computer-Aided Design, Synthesis, and Bioassay of Vasodilatory Active Pyridines. 14851, 2013. (Provisional Application)
- Facile Synthesis, Bioassay of Antiproliferative Active Dispiroindoles. 14878, 2013. (Provisional Application)
Book Chapter
A Full Cycle Mosquito Repellent Discovery: Molecular Docking, QSAR, Synthesis, and Bioassay. Computational design of chemicals for the control of mosquitoes and their diseases, CRC Press. 2017. (Under preparation) – I am a co-author.
Research Publications
2017
- Zhang H.; Wang, Z.; Ghiviriga, I.; Pillai, G. G.; Jabeen, F.; Arami, J.A.; H.M.; Zhou W.; Steel, P.J.; Hall, C.D.; Katritzky, A.R. Synthesis, Characterization and Energetic Properties of Novel 1-Methyl-1,2,4-Triazolium N-Aryl / N-Pyridinyl Ylids. Tetrahedron Lett. Just Accepted (2017). Impact Factor: 2.34
- Girgis, A. S.; Srour, A. M.; Farag, H.; Ismail, N. S. M.; Elgendy, M.; Abdel-Aziz, A. K.; Panda, C. S.; Pillai G. G.; Katritzky, A. R. Design, Synthesis, and QSAR Studies of Novel Antiproliferative Dispiroindoles Against Melanoma Cell Lines. RSC Advances. 2016 (Submitted)
- Shrivastava, J. K.; Pillai, G. G.; Verma, A.; Bhat, H. R.; Singh, U. P. Design and Discovery of Novel 1,3,5-triazine-3,4-dihydro-1H-pyrimidine Conjugates as Antiproliferative Agent via attenuating epidermal growth factor receptor (EGFR) - tyrosine kinase along with Antibacterial and Antifungal Activity. Scientific Reports 2017 (Submitted)
- Pillai, G. G.; Gronski, A.; Mederos, L.; Tämm, K.; Hall, C. D.; Katritzky, A. R.; Karelson, M. Scaffold Field point analysis to compare target activities for CDK1, CDK2 & CDK4 Inhibitors. (Manuscript under preparation)
- Zhang H.; Wang, Z.; Jabeen, F.; Pillai, G. G.; Yeung, J.; Zhou W.; Steel, P.J.; Hall, C.D.; Katritzky, A.R. Synthesis of pyridinium N-aryl/N-heteroarylcyclic ylides as potential energetic materials. Tetrahedron Lett. 57(1), 20-24, (2016). Impact Factor: 2.34 Citations: 01
- Chowdhury, L.; Celine, J C.; Goel S.; Zaman, N.; Tai, A. C-S.; Walch, E.M.; Smith, K.; Page, A.; Shea, K.M.; Hall, C.D.; Jishkariani, D.; Pillai, G. G.; Hall, A.C.; Differential Potency of 2, 6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA Receptor Currents, J. Pharm. Exp. Therap., 357(3), 570-579, (2016). Impact Factor: 3.76 –Issue Frontispiece
- Zhang H.; Wang, Z.; Jabeen, F.; Pillai, G. G.; Yeung, J.; Sibble, A.J.; Mathelier, M.; Berman, H.M.; Zhou W.; Steel, P.J.; Hall, C.D.; Katritzky, A.R. The synthesis and energetic properties of pyridinium and triazolium N-(nitrobenzoyl)-imides. ARKIVOC, III, 99-109 (2016). Impact Factor: 1.165
- Bajaj, K.; Sakhuja, R.; Pillai, G. G. Traceless reductive ligation at a tryptophan site: a facile access to β-hydroxytryptophan appended peptides. Org. Biomol. Chem.,14, 9578-9587. (2016). Impact Factor: 3.90
- Girgis, A. S.; Panda, S.S.; Farag, I. S. A.; El-Shabiny, A. M.; Moustafa, A. M.; Ismail, N. M.; Pillai, G. G.; Panda, C. S.; Hall, C.D.; Katritzky, A. R. Synthesis, and QSAR analysis of anti-oncological active spiro-alkaloids. Org. Biomol. Chem., 13, 1741-1753 (2015) Impact Factor: 3.56 Citations: 13
- Pillai, G.G.; Sikk, L.; Tamm, T.; Karelson, M.; Burk, P.; Tämm, K. Theoretical Modeling of HPV: QSAR and Novodesign with Fragment Approach, Curr. Comput. Aided Drug Des. 10 (4), 303-314 (2015). Impact Factor: 2.80 Citations: 01
- Girgis, A. S.; Saleh, D. O.; George, R. F.; Srour, A. M.; Pillai, G. G.; Panda, C. S.; Katritzky, A. R. Synthesis, bioassay, and QSAR study of bronchodilatory active 4H-pyrano[3,2-c] pyridine-3-carbonitriles. Eur. J. Med. Chem. 89, 835-843 (2015). Impact Factor: 3.90 Citations: 06
- Ibrahim, M. A.; Panda S. S.; Oliferenko, A. A.; Kucukbay F. Z.; Panda, C. S.; Pillai, G. G.; Samir A.; Girgis A. S.; Hall, C. D.; Katritzky, A. R. Macrocyclic Peptidomimetics with Antifungal and Antibacterial Activity: Synthesis, Bioassay, and Putative Mechanism of Action Org. Biomol. Chem., 13 (36), 9492-9503 (2015). Impact Factor: 3.90 Citations: 12
- Pillai, G. G.; Mederos, L.; Panda, C. S.; Tämm, K.; Hall, C. D.; Katritzky, A. R.; Karelson, M. Robust QSAR Modeling and Scaffold Hopping: Case Study based on HIV Reverse Transcriptase Inhibitors Type-1 Data. Medicinal Chemistry. 12(6), 513-526 (2015). Impact Factor: 1.45 Citations: 01
- Wang, Z.; Zhang H.; Killian, B. J.; Jabeen, F.; Pillai, G. G.; Berman, H.M.; Mathelier, M.; Sibble, A.J.; Yeung, J.; Zhou W.; Steel, P.J.; Hall, C.D.; Katritzky, A.R. Synthesis, Characterization and Energetic Properties of 1, 3, 4‐Oxadiazoles Euro. J. Org. Chem. 23, 5183-5188 (2015). Impact Factor: 3.06 Citations: 01
- Dearden J.C., Hewitt M., Roberts D.W., Enoch SJ, Rowe PH, Przybylak KR, Vaughan-Williams GD, Smith ML, Pillai, G. G.; Katritzky, A. R Mechanism-Based QSAR Modeling of Skin Sensitization, Chem. Res. Tox. 28(10), 1975-1986 (2015). Impact Factor: 3.03 Citations: 05
- Wang, Z.; Zhang H.; Jabeen, F.; Pillai, G. G.; Arami, J.A.; Killian, B.J.;.Steigler, K.D.; Yudewitz, D.S.; Thiemann, P.L.; Turk, J.D.; Zhou W.; Steel, P.J.; Hall, C.D.; Katritzky, A.R. Synthesis and Properties of Energetic 1, 2, 4‐Oxadiazoles. Eur. J. Org. Chem. 34, 7468-7474 (2015). Impact Factor: 3.06 Citations: 01
- Biswas, S.; Kayaleh, R.; Pillai, G. G.; Seon, C.; Roberts, I.; Popov, V.; Alamry, K. A.; Katritzky, A. R. Long-range chemical ligation from N→N acyl migrations in tryptophan peptides via cyclic transition states of 10- to 18-members. Chemistry Euro. J. 20, 8189–98 (2014). Impact Factor: 5.77 Citations: 06
- Ha, K.; Lebedyeva, I.; Hamedzadeh, S.; Li, Z.; Quiñones, R.; Pillai, G. G.; Williams, B.; Nasajpour, A.; Martin, K.; Asiri, A. M.; Katritzky, A. R. Tandem deprotection-dimerization-macrocyclization route to C(2) symmetric cyclo-tetrapeptides. Chemistry Euro. J. 20, 4874–9 (2014). Impact Factor: 5.77 Citations: 05 Issue Frontispiece
- Jabeen, F.; Oliferenko, P. V; Oliferenko, A. A.; Pillai, G. G.; Ansari, F. L.; Hall, C. D.; Katritzky, A. R. Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis. Eur. J. Med. Chem. 80, 228-242, (2014). Impact Factor: 3.90 Citations: 04
- Oliferenko, P. V; Oliferenko, A. A.; Girgis, A. S.; Saleh, D. O.; Srour, A. M.; George, R. F.; Pillai, G. G.; Panda, C. S.; Hall, C. D.; Katritzky, A. R. Synthesis, bioassay, and molecular field topology analysis of diverse vasodilatory heterocycles. J. Chem. Inf. Model. 54, 1103–16 (2014). Impact Factor: 3.68 Citations : 04
- Dobchev, D. A.; Pillai, G. G.; Karelson, M. In silico machine learning methods in drug development. Curr. Top. Med. Chem. 14(16), 1913-1922 (2014). Impact Factor: 2.90 Citations: 10
- Li, Z.; Lebedyeva, I.; Zhao, D.; Myers, L.; Pillai, G. G.; Hall, C.D.; Alamry, K. A.; Katritzky, A. R. Synthesis and Stability Assay for L-Lys-Amonixy-Goralatide, J. Peptides 20(12), 923-927 (2014). Impact Factor: 1.95 Citations: 01
- El-Gendy, B. E.-D. M., Ghazvini Zadeh, E. H., Sotuyo, A. C., Pillai, G. G. & Katritzky, A. R. α-Substitution effects on the ease of S→N-acyl transfer in aminothioesters. Chem. Biol. Drug Des. 81, 577–82 (2013). Impact Factor: 2.80 Citations: 04
- Ha, K.; Lebedyeva, I.; Li, Z.; Martin, K.; Williams, B.; Faby, E.; Nasajpour, A.; Pillai, G. G.; Al-Youbi, A. O.; Katritzky, A. R. Conformationally assisted lactamizations for the synthesis of symmetrical and unsymmetrical bis-2,5-diketopiperazines. J. Org. Chem. 78, 8510–23 (2013). Impact Factor: 4.79 Citations: 03
- Oliferenko, P. V.; Oliferenko, A. A.; Poda, G. I.; Osolodkin, D. I.; Pillai, G. G.; Bernier, U. R.; Tsikolia, M.; Agramonte, N. M.; Clark, G. G.; Linthicum, K. J.; Katritzky, A. R. Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay. PLoS One 8, e64547 (2013). Impact Factor: 3.23 Citations: 11
- Berhanu, W. M., Pillai, G. G., Oliferenko, A. A. & Katritzky, A. R. Quantitative Structure-Activity/Property Relationships: The Ubiquitous Links between Cause and Effect. Chempluschem 77, 507–517 (2012). Impact Factor: 2.83 Citations: 32
- Berhanu, W. M.; Ibrahim, M. A.; Pillai, G. G.; Oliferenko, A. A.; Khelashvili, L.; Jabeen, F.; Mirza, B.; Ansari, F. L.; Ul-Haq, I.; El-Feky, S. A.; Katritzky, A. R. Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics. Beilstein J. Org. Chem. 8, 1146–60 (2012). Impact Factor: 2.70 Citations: 10
- Ha, K.; Monbaliu, J.-C. M.; Williams, B. C.; Pillai, G. G.; Ocampo, C. E.; Zeller, M.; Stevens, C. V; Katritzky, A. R. A convenient synthesis of difficult medium-sized cyclic peptides by Staudinger mediated ring-closure. Org. Biomol. Chem. 10, 8055–8 (2012). Impact Factor: 3.60 Citations: 12
- Singh, N. K.; Pakkkianathan, B. C.; Kumar, M.; Daddam, J. R.; Jayavel, S.; Kannan, M.; Pillai, G. G.; Krishnan, M. Computational studies on molecular interactions of 6-thioguanosine analogs with anthrax toxin receptor 1. Interdiscip. Sci. 4, 183–9 (2012). Impact Factor: 0.83 Citations: 01
- Zhong, M., Jang, M., Oliferenko, A., Pillai, G. G. & Katritzky, A. R. The SOA formation model combined with semiempirical quantum chemistry for predicting UV-Vis absorption of secondary organic aerosols. Phys. Chem. Chem. Phys. 14, 9058–66 (2012). Impact Factor: 4.45 Citations: 12
Awards & Scholarships
- Marie Curie Actions Research Fellow, FP7/People Programme, 612275, Estonia, 2015.
- Vega Fond - SEB Award, Won Start-up Idea pitching Competition and €2200, 2014.
- Kaleidoscope – Tartu City Award, Won Idea pitching Competition and €500, 2014.
- Graduate School Research Scholarship, European Social Fund (1.2.0401.09-0079), Estonia, 2013.
- Research Project Support, Estonian Ministry of Education and Research (SF0140031As09), 2012.
- Project Funding Support, US Department of Agriculture, 2011.
- University First Rank Scholarship, Bharathidasan University, 2006.
- Project Studentship on Malaria, Tamilnadu State Council for Science & Technology, 2005.
- Academic Council Member, Department of Chemistry, S.N. College (Kerala University), Chengannur, Kerala, India. 2010.
- Academic Council Member, Department of Bioinformatics, Karunya University, Coimbatore, Tamilnadu, India. 2009.
Non-peer reviewed Publications
- Approach of Nano-Particles based Dosage forms for efficient Drug Delivery. Pillai, G. G.; Stephan, R. AICTE Journal Proceedings 2006 Vol II.
- Identification of New Drug Targets for Malaria, Pillai, G.G.; Jayalakshmi, R. TNSCST Annual Proceedings. 2006 Vol III.
- Computational Approach on Protein Redesigning, Pillai, G. G.; Rajasree, H.; Dhar, P. K. BioDesign India 1.0, CSSB, University of Kerala, India. 2011.
- QSAR Prediction of HIV-1 Non-nucleoside Inhibitor Activity based on 3D-Molecular Descriptors. Pillai, G. G.; Tämm, K.; Karelson, M. FMTDK Conference Proceedings, Tartu, Estonia. 2014.
- Synthesis and QSAR studies of some novel disubstituted 1, 2, 4-triazoles as antimicrobial agents. Panda, S.S.; Jain, S.C.; Pillai, G.G. (mention & contribution), Medicinal Chemistry Research, 23(2), 848-861. 2014.
Conference (Oral/Poster)
- Modelling of catalytic reactions using MedeA, X. Rozanska, G. G. Pillai, Bangalore India Nano, Bengaluru, India. 2016
- Quantum chemistry and drug delivery, G.G. Pillai, 68th Indian Chemical Engineering Congress CHEMCON 2015, Guwahati, India. 2015.
- In silico designing of human monoamine oxidase inhibitors. F. Jabeen, C. S. Panda, G. G. Pillai, A. R. Katritzky, 248th ACS Meeting, USA. 2014.
- QSAR Prediction of diverse scaffolds of HIV-1 Non-nucleoside Inhibitor Activity based on 3D/4D-Molecular Descriptors. G. G. Pillai, K. Tämm, M. Karelson. FMTDK Conference, Tartu, Estonia. 2014.
- Mathematical Model to compare bio-assays of CDK inhibitors. G. G. Pillai, A. Gronski, L. Mederos, M. Karelson, A. R. Katritzky. FloHet Conference, Gainesville, FL. 2014.
- In-silico understanding of the mode of action in Mosquito Repellents. G. G. Pillai, A. Oliferenko, A. R. Katritzky. FloHet Conference, Gainesville, FL. 2012.
- Computational Approach on Protein Redesigning, G. G. Pillai, H. Rajasree, P. K. Dhar. BioDesign India 1.0, CSSB, University of Kerala, India. 2011.
- Identification of New Drug Targets for Malaria, G.G. Pillai, Jayalakshmi, R., TNSCSTE, 2011
- COSMO-RS Symposium 2009 - Leverkusen, Germany, March, 2009
- International Conference on Chemoinformatics - Cochin, India, August, 2009
- BioDesign India 1.0 - Synthetic Biology - Trivandrum, India, October, 2010
- Annual Florida Heterocyclic and Synthetic Conference - Florida, USA, March, 2012
- Open Eye's CUP XIII - New Mexico, USA, March, 2012